By Dr. Nitesh Rohatgi & Dr. Sudhir Borgonha IANS |February 3 Every family has had close relatives who have been victims of cancer. In most cases, we feel the pangs of the suffering and are concerned about what they and their immediate families must be going through. But we often do not pay the necessary amount of attention to how this could impact us until someone who is extremely close to us such as our parents or siblings is diagnosed. Then we are often left thinking: "If we could have done something to prevent this and if there was a way that this risk could have been minimised." It also raises the question if we are also at risk of developing cancer. Up to 10 per cent of cancer cases have a hereditary component. This essentially means that despite healthy lifestyle habits, if we have inherited a bad copy of a gene that plays a role in cell renewal, we are always at a greater risk of developing cancer. Two of the best-known such genes are BRCA1 and BRCA2, which infer a significantly increased risk of getting breast and ovarian cancer if a mutation is present in either of these genes. Scientific and medical research shows that there are several other genes that may cause cancer in a similar manner. Some gene mutations are responsible for specific cancer types, while others are involved in many types of cancers, complicating the effect-and-cause scenario significantly. It requires experts in genetics and cancer to shed light on what caused a cancer and choosing the right treatment. Genetic counsellors are trained to understand a patient's family history of illnesses, including cancers, and draw up scientifically valid "pedigree charts" (or a family tree) to map a disease across up to three generations or more. This specialised training uniquely qualifies them to understand a person's family history of a disease like cancer. They are skilled at interpreting this knowledge and can provide accurate predictions of the risks faced by a person who makes use of their services. Additionally, genetic counsellors can explain the consequences of inheriting bad cancer genes to patients, family members, as well as doctors. Hence, genetic counsellors fill this important information gap both for explaining the importance of genetics to families and working with doctors to get the best diagnostics and treatment for their patients. Today, genetic counsellors can use not only their training and experience but also highly sophisticated prediction software to interpret a person's family history. Using this information, they can determine whether a person is at a higher risk of developing cancer in his or her lifetime compared to the average cancer risk of about 1-2 per cent for most cancer types. Once the genetic counsellor is certain that there is a significantly increased risk, he can recommend the appropriate genetic tests. These tests can identify whether a disease-causing gene mutation is present in a person's DNA or not and allow a genetic counsellor to calculate a person's risk for getting cancer even more accurately.